Autoamplification of NFATc1 expression determines its essential role in bone homeostasis
نویسندگان
چکیده
منابع مشابه
Autoamplification of NFATc1 expression determines its essential role in bone homeostasis
NFATc1 and NFATc2 are functionally redundant in the immune system, but it was suggested that NFATc1 is required exclusively for differentiation of osteoclasts in the skeletal system. Here we provide genetic evidence that NFATc1 is essential for osteoclast differentiation in vivo by adoptive transfer of NFATc1(-/-) hematopoietic stem cells to osteoclast-deficient Fos(-/-) mice, and by Fos(-/-) b...
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Activation of calcineurin-dependent nuclear factor of activated T cells c1 (NFATc1) is convergent for normal bone homeostasis. NFATc1 regulates both osteoclastogenesis and osteoblastogenesis. Here we investigated the roles of regulator of calcineurin (RCAN) genes in bone homeostasis. RCANs function as potent physiological inhibitors of calcineurin. Overexpression of RCANs in osteoclast precurso...
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1 To whom correspondence should be addressed: The Harry B. & Aileen B. Gordon Diabetes Research Center, 1102 Bates, Suite 550, MC 3-2353, Houston, TX 77030. Tel: 832-8243764; FAX: 832-825-3766. E-mail: [email protected] 2 Current address: Department of Physiology & Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR 72205 3 The abbreviations used are: AR, aldose reductase...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2005
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.20051150